Heart Disease 
One of the best ways to help prevent and treat heart disease is to eat a low-fat diet and to replace foods rich in saturated and trans-fat with those that are rich in monounsaturated and polyunsaturated fats (particularly omega-3 fatty acids). In addition to reducing risk factors for heart disease, namely high blood pressure and elevated cholesterol, evidence suggests that people who eat an ALA-rich diet are less likely to suffer a fatal heart attack.

High Cholesterol
People who follow a Mediterranean-style diet tend to have higher HDL ("good") cholesterol levels. This diet consists of a healthy balance between omega-3 and omega-6 fatty acids. It emphasizes whole grains, root and green vegetables, daily intake of fruit, fish and poultry, olive and canola oils, and ALA, along with discouragement of ingestion of red meat and total avoidance of butter and cream. In addition, ALA have been shown to lower cholesterol and triglycerides in people with high cholesterol.

High Blood Pressure
Several studies suggest that diets and/or supplements rich in omega-3 fatty acids (including ALA) lower blood pressure significantly in people with hypertension. Fish high in mercury (such as tuna) should be avoided, however, because they may increase blood pressure.

Acne
Although there are few studies to support the use of omega-3 fatty acids for skin problems, many clinicians believe that flaxseed is helpful for treating acne.

Arthritis
Several studies suggest that ALA supplements reduce tenderness in joints, decrease morning stiffness, and improve mobility. Many people who take these supplements report that they do not need as much medicine to relieve their painful symptoms.

Asthma
Preliminary research suggests that omega-3 fatty acid supplements (particularly perilla seed oil which is rich in ALA) may decrease inflammation and improve lung function in adults with asthma.

Eating Disorders
Studies suggest that men and women with anorexia nervosa have lower than optimal levels of polyunsaturated fatty acids (including ALA and GLA). To prevent the complications associated with essential fatty acid deficiencies, some experts recommend that treatment programs for anorexia nervosa include PUFA-rich foods or supplements.

Inflammatory Bowel Disease (IBD)
Some people with Crohn's disease (CD), one form of IBD, have low levels of omega-3 fatty acids in their bodies. Evidence suggests that fish oil supplements containing omega-3 fatty acids may reduce symptoms of CD and ulcerative colitis (another inflammatory bowel disease), particularly if used in addition to medication. Preliminary animal studies have found that ALA may actually be more effective than EPA and DHA found in fish oil supplements.